Genomic, Proteomic, and Metabolomic Data Integration Strategies
نویسندگان
چکیده
منابع مشابه
Genomic, Proteomic, and Metabolomic Data Integration Strategies
Robust interpretation of experimental results measuring discreet biological domains remains a significant challenge in the face of complex biochemical regulation processes such as organismal versus tissue versus cellular metabolism, epigenetics, and protein post-translational modification. Integration of analyses carried out across multiple measurement or omic platforms is an emerging approach ...
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Statistical mining and integration of complex molecular data including metabolites, proteins, and transcripts is one of the critical goals of systems biology (Ideker, T., Galitski, T., and Hood, L. (2001) A new approach to decoding life: systems biology. Annu. Rev. Genomics Hum. Genet. 2, 343-372). A number of studies have demonstrated the parallel analysis of metabolites and large scale transc...
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Motivation and Objectives With high-throughput technologies in the life sciences, particularly in molecular biology, the amount of data available has grown exponentially. Yet, such data are stored in several different formats and spread into numerous databanks (Galperin and Fernández-Suárez, 2012). This scenario makes even more difficult to find and retrieve the data required to answer the scie...
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Organic acidemias (OAs) are inherited metabolic disorders caused by deficiency of enzymatic activities in the catabolism of amino acids, carbohydrates, or lipids. These disorders result in the accumulation of mono-, di-, or tricarboxylic acids, generally referred to as organic acids. The OA outcomes can involve different organs and/or systems. Some OA disorders are easily managed if promptly di...
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Metabolomics is a rapidly growing field consisting of the analysis of a large number of metabolites at a system scale. The two major goals of metabolomics are the identification of the metabolites characterizing each organism state and the measurement of their dynamics under different situations (e.g. pathological conditions, environmental factors). Knowledge about metabolites is crucial for th...
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ژورنال
عنوان ژورنال: Biomarker Insights
سال: 2015
ISSN: 1177-2719,1177-2719
DOI: 10.4137/bmi.s29511